Home Depot epoxy is probably 2 part 1:1 resin and hardener. West system is 5:1.
I believe 5:1 is superior for strength for epoxy (the resin is the strong stuff, so you want more of that).
West has been around forever in the same formula so it’s very very commonly used which makes it the standard.
They make pumps for it to mix it in the proper ratio but the quantity ends up being more than you need for guitar stuff I mix it in 5 gram increments (5g resin 1g hardener) on a little druggy scale from Amazon. It pays to get the ratio as close to perfect as possible. Usually I do 10g.
You can use it for whatever you normally use glue for. Things to remember is that it isn’t reversible in any way like hide glue, it can make a huge mess, it’s somewhat toxic.
What I really like a lot is the West G-Flex gel which is a 2 part but almost as strong as regular west but slightly more flexible. I think that’s probably a good thing for guitars in that it will bend before failing. It’s easy and fast to mix. Definitely get the gel not the liquid.
I do use west for some finishing stuff and the Amine Blush part of west is an annoying issue. I will probably switch to system 3 because of that.